Phosphorylase b kinase inheritance in mice.

Liver Phosphorylase Kinase

a deficiency of liver phosphorylase kinase, causing a lack of active glycogen phosphorylase, although total phosphorylase is normal. The intravenous injection of glucagon caused a rapid activation of cyclic AMP-dependent protein kinase in the liver, but no increase in either phosphorylase kinase or phosphorylase a activity. Although total glycogen synthase activity in the livers of affected rat...

X-Linked Liver Phosphorylase Kinase Deficiency Is Associated with Mutations in the Human Liver Phosphorylase Kinase a Subunit

Glycogenolysis during Tetanic Contraction of Isolated Mouse Muscles in the Presence and Absence of Phosphorylase A.

Muscle contraction may increase the rate of glycogen degradation to several hundred times that present at rest (1, 2). The increase in the rate of conversion of glycogen to lactate in isolated frog sartorius performing single twitches requires changes in the activity of at least two enzymes, glycogen phosphorylase and phosphofructokinase (2). The activation of phosphorylase and control of rapid...

Calcium-dependent phosphorylation of glycogen synthase by phosphorylase kinase.

Purified preparations of rabbit skeletal muscle glycogen synthase (specific activity 6 to 42 units/mg of protein) were found to be contaminated with calciumdependent kinase(s) which catalyzed the phosphorylation of glycogen phosphorylase b and glycogen synthase. In a series of glycogen synthase preparations there was a correlation between the phosphorylation rates of glycogen synthase and of ad...

Studies on Phosphorylase Activation in the Heart.

It is well known that stimulation of the heart by epinephrine and other sympathomimetic amines causes activation of glycogen phosphorylase, i.e. conversion of phosphorylase b to phosphorylase a, either in the intact animal or in the isolated organ (l-5). This reaction appears to be analogous to that occurring in skeletal muscle (6-8) and is catalyzed by phosphorylase b kinase. In skeletal muscl...